Profiles illustrating potential clinical presentations of patients with CSU. The below profiles are hypothetical and for illustrative purposes only.





  • Age 62
  • Retired policeman


  • Spontaneous itchy hives for over 14 years
  • >60 erythematous lesions with central swelling on torso, arms, face and neck
  • Angioedema of lips and 3 episodes of tongue swelling
  • No identified triggers
  • Inadequate response to high-dose H1-antihistamines*
  • Several courses of oral corticosteroids*

Clinical characteristics

  • Full blood count and CRP normal, ASST negative
  • UAS7 = 30 and DLQI = 22
  • Diagnosis: chronic spontaneous urticaria with angioedema




  • Age 35
  • Primary school teacher and single mother


  • Spontaneous itchy hives for over 4 years
  • Pale, erythematous, raised, itchy lesions (>40) on the upper back, neck, both arms and face
  • No identified triggers
  • Inadequate response to high-dose H1-antihistamines*
  • Inadequate response to montelukast as add-on treatment*

Clinical characteristics

  • Skin prick test negative, full blood count and CRP normal
  • UAS7 = 28 and DLQI = 16
  • Diagnosis: chronic spontaneous urticaria



*Not licensed in CSU.

ASST, autologous serum skin test; CRP, c-reactive protein; CSU, chronic spontaneous urticaria; DLQI, Dermatology Life Quality index; UAS7, urticaria activity score (seven days). 

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UK | October 2021 | 146364

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